Complete amelanotic acral nodular melanoma

Amelanotic malignant melanoma in an acral location.

We present the case of a 74-year-old white female admitted to the Department of Dermatology because of a tumor in the IV-V interdigital area of her right foot. A crimson, dome-shaped tumor with a granular, spongy surface (diameter 4 cm) had developed over a period of about 3 months. The biopsy, stained with H and E, revealed an anaplastic malignant tumor. Additional immunochemical staining with...

Amelanotic Acral Melanoma Associated with KIT Mutation and Vitiligo

Amelanotic acral melanoma is rare and difficult to diagnose, both clinically and pathologically. KIT mutations are frequently found in acral melanomas and are considered a risk factor for poor prognosis. The presence of vitiligo in melanoma has been reported, and KIT is thought to be partly responsible for the dysfunction and loss of melanocytes observed in vitiligo. We report a case of amelano...

Nodular Melanoma

Subungual amelanotic malignant melanoma.

We report a 61-year-old, male patient complaining from prolonged lesion on his great toe that has been previously treated surgically. Histopathological examination of toenail specimen revealed the presence of nests of atypical tumor cells that led to the diagnosis of amelanotic malignant melanoma. Four years ago, he was diagnosed as gout due to extreme erythema and edema in the same toe. He has...

Multifocal amelanotic conjunctival melanoma

Clinical and histopathological features of four cases of multifocal amelanotic malignant melanoma of the conjunctiva in association with 'acquired melanosis sine pigmento' are reported. The absence ofconjunctival pigmentation in this extremely rare combination of lesions prevented early diagnosis and clinical monitoring. As a result orbital exenteration was required in three cases. This multice...